Endocrine Abstracts

A 44-year old male patient with HIV-1 stage C2 presented with intermittent fever and weight loss (10 kg in 3 months). He was being treated with tenofovir/emtricitabine and atazanavir, and had a CD4 levels of 705/mm3 and HIV viral load of 1400 copies/ml. Upon admission, the complete blood panel showed anaemia and thrombocytopenia (haemoglobin: 75 g/l, platelets: 98 G/l), normal white blood cell count, normal hepatic tests and renal function, normal electrolytes and a...

Background: Numerous observational studies suggested that variation in thyroid function parameters even within the normal range associates with adverse, in particular non-thyroidal, health outcomes, but causality for most remains to be established.Methods: We combined individual level and summary level genetic prediction methods, i.e., polygenic scores and Mendelian randomization (MR), to systematically test for an association between liability to variat...